ABSTRACT
Objective:To explore the association of HSP90B1 gene polymorphisms with susceptibility of systemic lupus erythematosus(SLE) in Chinese Han population.Methods: We recruited 360 SLE patients from hospital as case group and selected 360 age- and sex-matched individuals without autoimmune diseases as control group.Multiplex SNaPshot was used for genotyp-ing.Benjamin-Hamburg(BH) method based on false discovery rate(FDR) standard was used for multiple testing correction.Results:The rs1165681 polymorphism(Crude OR=0.621,95% CI=0.450-0.856,P=0.004;Adjusted OR=0.619,95% CI=0.449-0.855,P=0.004) was significantly associated with SLE risk reduction in dominant model,and the rs10778306 polymorphism(crude OR=0.568, 95% CI=0.328-0.984,P=0.044;Adjusted OR=0.570,95% CI=0.329-0.988,P=0.045) and the rs2722188 polymorphism(Crude OR=0.227,95% CI=0.076-0.681,P=0.008;Adjusted OR=0.227,95% CI=0.076-0.682,P=0.008) were significantly associated with SLE risk reduction in recessive model.After adjustment using BH method,genotype distribution of rs1165681 was statistical difference in two groups(PBH= 0.044).Significant associations were found between four haplotypes of HSP90B1 gene CCATTAGGCAT (OR=0.323,95% CI=0.154-0.680,P=0.002),CCCTTAGGCAC(OR=1.324,95% CI=1.014-1.729,P=0.039),TCCCTAGTCGC (OR=0.465,95% CI=0.221-0.979,P=0.039)and TTCTCGGGCAT(OR=0.443,95% CI=0.224-0.875,P=0.016)and SLE risk.After adjustment using BH method,the frequency of CCATTAGGCAT distribution difference was statistically significant in two groups(PBH= 0.028),but there were no statistical difference in other haplotypes frequency distributions (P>0.05).Conclusion:HSP90B1gene polymorphisms may be associated with the susceptibility of SLE in Chinese Han population.